Acyclovir is generally well tolerated; GI upset and headache are the most frequent pediatric complaints. Serious renal or neurologic effects are rare and usually linked to dehydration or impaired kidney function.
Hydration and renal monitoring in high-risk children mitigate most adverse effects.
2 documented effects
Not specified
Give with food and small frequent sips of fluids.
Call if persistent vomiting or signs of dehydration.
Not specified
Supportive care, hydration, BRAT-style diet if tolerated.
Call for bloody stools, high fever, or dehydration.
2 documented effects
Not specified
Use age-appropriate analgesics as directed; maintain hydration.
Monitor for symptom escalation or new adverse effects.
Not specified
Stop medication and seek urgent medical evaluation.
Watch for new confusion, agitation, or hallucinations—especially in renal disease.
1 documented effect
Not specified
Stop drug, ensure hydration, obtain labs per clinician.
Monitor urine output; call for reduced urination or flank pain.
1 documented effect
Not specified
Stop medication and contact clinician; evaluate for allergy.
Monitor for symptom escalation or new adverse effects.
For babies taking Acyclovir, watch for signs of side effects. This medication is generally well-tolerated in infants when used as directed.
This medicine helps fight the germ causing your sores. Sip water often.
Acyclovir helps slow down the virus so you heal faster. Drinking water keeps your kidneys happy.
Stay on schedule and hydrate to protect your kidneys while on this antiviral.
A: Give doses with a light snack and keep fluids flowing.
When to validate: Call if vomiting persists or your child cannot keep fluids down.
A: Kidney issues are uncommon with good hydration and correct dosing.
When to validate: Call if urine output drops or there is flank/back pain.
Clinical assessment framework for Acyclovir adverse effects using standardized severity grading.
Parent and clinician concerns about Acyclovir