Assess beta-lactam allergy history, renal function, and previous antibiotic tolerance when selecting cefadroxil.
Absolute contraindications include prior anaphylaxis or severe cutaneous reactions to cefadroxil or related cephalosporins. Relative contraindications focus on children with high-risk penicillin allergies, chronic kidney disease, or recurrent C. difficile infection.
Documented anaphylaxis, angioedema, or severe cutaneous adverse reaction to cefadroxil or any cephalosporin
Known hypersensitivity to formulation ingredients
History of IgE-mediated penicillin allergy—assess for cross-reactivity before use
Creatinine clearance <30 mL/min—extend dosing interval to prevent accumulation
Prior Clostridioides difficile infection or chronic colitis—monitor for recurrence
Phenylketonuria—powder for suspension contains phenylalanine
Long-term therapy in renal or hepatic impairment—monitor renal function, liver enzymes, and CBC