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Peds Calc

Clinical Wisdom

Cefadroxil Clinical PearlsExpert Tips & Parent Guide

Use these pearls to maximize cefadroxil’s convenience while minimizing resistance risk.

Quality Score: 9/10
0 Evidence Sources
0 Practice-Changing Updates
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Essential Clinical Pearls

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Once-daily is OK for strep throat

Cefadroxil’s long half-life allows 30 mg/kg once daily (max 1 g) for 10 daysβ€”great for families struggling with midday school dosing.

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Double-check penicillin allergy

Most β€œpenicillin allergies” are benign rashes. If history is remote or vague, consider referral for penicillin testing so future infections can use narrower agents.

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Set finishing checkpoints

Schedule a 10-day completion reminder in the EHR to confirm symptom resolution and adherence, preventing rheumatic fever.

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Encourage hydration

Adequate fluids reduce GI upset and help prevent crystalluria in renal impairmentβ€”especially important when once-daily doses are concentrated.