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Peds Calc

Pediatric Reference

Cefadroxil Side EffectsComprehensive Pediatric Safety Guide

Most side effects are mild and self‑limited. Gastrointestinal symptoms (diarrhea, nausea) and rash are most common in children. Serious reactions like anaphylaxis or C. difficile–associated diarrhea (CDAD) are rare but require urgent care.

4 Categories
6 Clinical Sources
Evidence-Based
Back to Cefadroxil Overview

Essential Information

1

Give with food to help reduce stomach upset.

2

Keep the child hydrated; call for severe or bloody diarrhea.

3

Stop immediately and seek urgent care for hives, facial swelling, or breathing trouble.

Clinical Overview

Cefadroxil’s pediatric safety profile is similar to other oral cephalosporins. GI upset often improves if given with food. Allergic reactions can occur in those with beta‑lactam hypersensitivity.

Side Effect Categories

4 Systems

Gastrointestinal

3 documented effects

Total Sources: 3

Diarrhea

Incidence: Common
Onset: Typically within the first 2–3 days
mild
1 sources
Duration

Not specified

Management

Maintain hydration; consider giving with food; avoid antidiarrheals unless instructed

Monitoring Guidelines

Call if severe, persistent >3 days, bloody, or accompanied by fever

1 clinical sources• PubMed • Clinical Guidelines • FDA

Nausea/Vomiting

Incidence: Common
Onset: Early in treatment
mild
1 sources
Duration

Not specified

Management

Give with food; small sips of fluids after dosing

Monitoring Guidelines

Call if persistent vomiting or signs of dehydration

1 clinical sources• PubMed • Clinical Guidelines • FDA

C. difficile–associated diarrhea (CDAD)

Incidence: Rare
Onset: During or up to several weeks after treatment
severe
1 sources
Duration

Not specified

Management

Stop drug; prompt clinical evaluation

Monitoring Guidelines

Watch for watery diarrhea, abdominal pain, fever; seek care immediately

1 clinical sources• PubMed • Clinical Guidelines • FDA

Skin

2 documented effects

Total Sources: 2

Rash (maculopapular)

Incidence: Common
Onset: Not specified
variable
1 sources
Duration

Not specified

Management

Call clinician for evaluation; continue if mild and child otherwise well unless advised

Monitoring Guidelines

Stop and seek urgent care for hives, facial swelling, mucosal involvement, or blistering

1 clinical sources• PubMed • Clinical Guidelines • FDA

Urticaria (hives)

Incidence: Uncommon
Onset: Not specified
moderate
1 sources
Duration

Not specified

Management

Stop medication and seek urgent care

Monitoring Guidelines

Monitor for symptom escalation or new adverse effects.

1 clinical sources• PubMed • Clinical Guidelines • FDA

Allergic/Immunologic

1 documented effect

Total Sources: 1

Anaphylaxis

Incidence: Rare
Onset: Not specified
severe
1 sources
Duration

Not specified

Management

Stop immediately; emergency care

Monitoring Guidelines

Monitor for symptom escalation or new adverse effects.

1 clinical sources• PubMed • Clinical Guidelines • FDA

Neurologic

1 documented effect

Total Sources: 0

Headache

Incidence: Common
Onset: Not specified
mild
Duration

Not specified

Management

Supportive care

Monitoring Guidelines

Monitor for symptom escalation or new adverse effects.

Parent Communication Guide

Age-Appropriate Explanations

Infants (0-12 months)

For babies taking cefadroxil, mild tummy upset can happen and usually goes away on its own.

Toddlers (1-3 years)

If your toddler is on cefadroxil, they might have a little stomach upset or loose stools. This is usually mild.

Children (4-12 years)

Cefadroxil can sometimes cause mild diarrhea or stomach upset. Encourage fluids and let us know if it’s persistent.

Adolescents (13+ years)

Some teens notice mild GI upset with cefadroxil. Taking with food can help unless told otherwise.

Common Parent Concerns

Q: Loose stools on cefadroxil

A: Mild diarrhea is common and often improves within a couple of days.

When to validate: Call if diarrhea is severe, bloody, or signs of dehydration appear.

Q: Rash while taking cefadroxil

A: A mild rash can occur. Seek urgent care for hives or breathing trouble.

When to validate: Stop medication and call urgently for hives, swelling, or breathing problems.

Clinical Decision Support

Severity Assessment Framework

Clinical assessment framework for cefadroxil adverse effects.

Mild
Indicators: Minimal GI upset
Action: Continue, supportive care
Moderate
Indicators: Persistent GI symptoms
Action: Supportive measures, consider timing with food, close follow-up
Severe
Indicators: Allergic signs, Severe diarrhea/dehydration
Action: Stop, evaluate urgently, consider alternative

Treatment Decision Guidelines

Immediate Discontinuation

  • Anaphylaxis/airway involvement
  • Severe cutaneous reaction

Consider Alternatives

  • Persistent moderate side effects

Dose Modification

  • Mild effects with good response

Clinical References

Cefadroxil — FDA DailyMedU.S. National Library of Medicine (2025)Label

Frequently Asked Questions

Parent and clinician concerns about Cefadroxil