Cefixime is a convenient once-daily beta-lactam, but stewardship and follow-up are critical to avoid resistance and missed failures.
Deploy cefixime after amoxicillin/clavulanate failure or intolerance. Document why first-line therapy is unsuitable to support antimicrobial stewardship metrics.
Confirm local susceptibility of H. influenzae and S. pneumoniae—resistance patterns vary seasonally.
Educate families that a single morning dose with breakfast maintains therapeutic levels and improves completion rates compared with thrice-daily cephalosporins.
Cefixime can trigger false-positive Clinitest results; use enzymatic assays if glucose monitoring necessary.