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Peds Calc

Pediatric Reference

Cefpodoxime Side EffectsComprehensive Pediatric Safety Guide

Cefpodoxime is generally well tolerated in children. Most side effects are mild and self‑limited.

2 Categories
0 Clinical Sources
Evidence-Based
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Essential Information

1

GI upset

nausea, abdominal discomfort, diarrhea — giving with food often helps.

2

Rash

typically maculopapular and mild; seek care urgently for hives, swelling, or breathing trouble.

3

Yeast overgrowth

diaper rash or oral thrush can occur—treat if symptomatic.

4

Rare

C. difficile‑associated diarrhea (CDAD) — evaluate if severe, persistent, or bloody diarrhea occurs.

Clinical Overview

Common effects include gastrointestinal upset and loose stools. Allergic reactions are uncommon but require urgent attention if they involve hives, swelling, or breathing difficulty.

Side Effect Categories

2 Systems

Gastrointestinal

2 documented effects

Total Sources: 0

Nausea/abdominal discomfort

Incidence: Common
Onset:
Mild
Duration

Management

Give with food; hydration

Monitoring Guidelines

Diarrhea

Incidence: Common
Onset:
Mild–moderate
Duration

Management

Fluids; seek care if severe, persistent, or bloody

Monitoring Guidelines

Dermatologic/Allergic

2 documented effects

Total Sources: 0

Maculopapular rash (delayed)

Incidence: Uncommon
Onset:
Mild–moderate
Duration

Management

Supportive; assess for allergy

Monitoring Guidelines

Urticaria/angioedema (IgE)

Incidence: Rare
Onset:
Severe
Duration

Management

Discontinue and seek urgent care

Monitoring Guidelines

Frequently Asked Questions

Parent and clinician concerns about Cefpodoxime