Review allergy history, renal function, and gastrointestinal tolerance before starting cefprozil.
Absolute contraindications include confirmed hypersensitivity or SCAR to cefprozil/cephalosporins. Relative contraindications involve severe penicillin allergy, renal impairment, and prior antibiotic-associated colitis requiring cautious use.
Documented immediate hypersensitivity (anaphylaxis, angioedema, severe cutaneous reaction) to cefprozil or other cephalosporins
Known hypersensitivity to formulation excipients
History of IgE-mediated penicillin allergy—evaluate cross-reactivity risk before prescribing
Creatinine clearance <30 mL/min (dose adjustment required to avoid accumulation)
Prior Clostridioides difficile-associated diarrhea—monitor for recurrence with any beta-lactam
Phenylketonuria—oral suspension contains aspartame
Prolonged therapy in patients with renal or hepatic impairment—monitor CBC, renal function, and liver enzymes