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Cefprozil Indications & Clinical Uses

Evidence-based guide for pediatric prescribing

Cefprozil is a second-generation cephalosporin used when aminopenicillins are ineffective or not tolerated in upper respiratory infections.

Primary FDA-Approved Indications

Consider cefprozil for acute otitis media, sinusitis, and streptococcal infections when beta-lactamase coverage is needed after first-line therapy.

Acute otitis media

FDA Approved
Children ≥6 monthsModerate

Preferred in non-IgE penicillin allergy when amox-clav is not tolerated.

Acute bacterial rhinosinusitis

FDA Approved
Children and adolescentsModerate

Use when amoxicillin/clavulanate is contraindicated or second-line per guideline algorithms.

Streptococcal pharyngitis

FDA Approved
Children and adolescentsModerate

Reserve for non-anaphylactic penicillin allergy; confirm GAS by rapid test/culture.

Secondary Clinical Uses

Skin and soft-tissue infections (MSSA, streptococci)

Secondary Use
Children and adolescents

Use when dicloxacillin or cephalexin not tolerated; culture-directed therapy recommended.

•Evidence quality: 75/10
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