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Peds Calc

Clinical Wisdom

Cefprozil Clinical PearlsExpert Tips & Parent Guide

Cefprozil bridges the gap between first-line amoxicillin and broader-spectrum cephalosporins. Use it judiciously to manage respiratory infections.

Quality Score: 9/10
0 Evidence Sources
0 Practice-Changing Updates
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Essential Clinical Pearls

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Verify true penicillin allergy

Document reaction details; refer for allergy testing when history is remote or vague to preserve narrow-spectrum options.

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Once-daily option improves completion

15 mg/kg once daily offers similar outcomes to 7.5 mg/kg BID for streptococcal infectionsβ€”use when families struggle with midday doses.

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Warn about serum sickness-like reactions

Rare immune-mediated rash with arthralgias can occurβ€”stop therapy and evaluate if urticaria, joint pain, or fever develops after several days.

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Space from antacids

Magnesium/aluminum antacids reduce cefprozil absorption; separate by 2 hours when possible.