Ceftibuten is an oral third-generation cephalosporin; vet allergy history, renal status, and GI risk factors before prescribing.
Absolute contraindications include previous anaphylaxis or SCAR to ceftibuten/cephalosporins. Relative contraindications include severe penicillin allergy, advanced renal impairment, and prior antibiotic-associated colitis. Suspension contains sucrose and may be dosed on an empty stomach—counsel caregivers accordingly.
Documented anaphylaxis or severe cutaneous reactions preclude further use; choose a non-beta-lactam agent.
Cross-reactivity is low but present; consider allergy evaluation or alternate therapy for severe histories.
Reduce dose or extend interval; monitor creatinine and for neurotoxicity.
Use cautiously in patients with a history of C. difficile; counsel about new-onset diarrhea.