Ceftibuten’s once-daily regimen supports adherence for escalation therapy. These pearls keep courses effective and safe.
Give suspension at least 1 hour before or 2 hours after meals; food reduces Cmax by ~20%. Add timing instructions to prescription labels.
For CrCl 30–50 mL/min, use 9 mg/kg once daily; if <30 mL/min, dose every 48 hours. Reinforce hydration to prevent crystalluria.
Record why ceftibuten is chosen (amox-clav failure, beta-lactam allergy) to justify broader spectrum use and inform future encounters.