Primary FDA-Approved Indications
Most pediatric use is for AOM and sinusitis as an alternative choice; for GAS pharyngitis it is an option when penicillins cannot be used.
Acute Otitis Media (AOM)
FDA ApprovedChildren ≥6 monthsLevel B
Alternative when amoxicillin/amoxicillin‑clavulanate cannot be used; dosed per clinician guidance (typical twice‑daily regimen).
Treatment Duration
Standard: 10 days (Range: 5–10 days)
Evidence Sources
UCSF IDMP: Cefuroxime ()
Acute Bacterial Rhinosinusitis
FDA ApprovedChildren and adolescentsLevel B
Consider in select cases when amoxicillin‑clavulanate is not appropriate; confirm bacterial criteria.
Treatment Duration
Standard: 10 days
Evidence Sources
Medscape: Cefuroxime ()
GAS Pharyngitis/Tonsillitis
FDA ApprovedChildren and adolescentsLevel B
Alternative option when penicillin or amoxicillin cannot be used; confirm diagnosis when possible.
Treatment Duration
Standard: 10 days
Evidence Sources
AAP Pharyngitis Guidance ()