Cimetidine is a competitive antagonist at histamine H2 receptors on gastric parietal cells and a potent inhibitor of multiple cytochrome P450 isoenzymes.
Cimetidine competitively blocks histamine at H2 receptors on gastric parietal cells, lowering basal and stimulated acid secretion. Its imidazole ring also inhibits hepatic CYP450 isoenzymes (1A2, 2D6, 3A4), accounting for many drug interactions.
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Half-life
Not specified
Primary Route
Not specified