Dimenhydrinate is a salt of diphenhydramine and 8-chlorotheophylline that combines antihistaminic and mild stimulant effects to control motion-induced nausea while limiting somnolence.
Dimenhydrinate combines diphenhydramine with chlorotheophylline. Diphenhydramine antagonizes histamine H1 receptors and exerts anticholinergic activity within the vestibular nuclei and chemoreceptor trigger zone, dampening the neuronal input that triggers nausea and vomiting. The xanthine component counterbalances excessive sedation.
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