Dimenhydrinate’s first-generation antihistamine properties cause sedation, anticholinergic effects, and, rarely, paradoxical agitation in young children.
Most adverse effects are mild and dose-related. Families should recognize signs of dehydration, urinary retention, and paradoxical CNS excitation.
2 documented effects
Not specified
Schedule doses during travel or bedtime; advise supervision for activities requiring coordination (swimming, biking).
Monitor for symptom escalation or new adverse effects.
Not specified
Discontinue immediately and seek medical evaluation; more common in children <6 years.
Monitor for symptom escalation or new adverse effects.
2 documented effects
Not specified
Offer sugar-free lozenges or water; monitor for dental hygiene impact.
Monitor for symptom escalation or new adverse effects.
Not specified
Encourage regular voiding; seek care if child cannot urinate or develops suprapubic pain.
Monitor for symptom escalation or new adverse effects.
1 documented effect
Not specified
Increase fluids and fiber; consider stool softener if prolonged use is necessary.
Monitor for symptom escalation or new adverse effects.
For babies taking Dimenhydrinate, watch for signs of side effects. This medication is generally well-tolerated in infants when used as directed.
If your toddler is taking Dimenhydrinate, they might feel different. This is usually temporary and normal.
This medicine may make you sleepy; sit down before you feel dizzy and tell us if your tummy or bladder hurts.
Take the smallest dose that works, avoid alcohol, and do not drive or operate bikes until you know how sleepy it makes you.
A: Expected effect. Keep activities quiet, but call if your child is difficult to wake or breathing abnormally.
When to validate: Seek urgent care if unresponsive or breathing slowly.
Clinical assessment framework for Dimenhydrinate adverse effects using standardized severity grading.
Parent and clinician concerns about Dimenhydrinate