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Doxycycline Indications & Clinical Uses

Evidence-based guide for pediatric prescribing

Doxycycline covers atypical and tick-borne pathogens with excellent oral bioavailability.

Primary FDA-Approved Indications

It is the drug of choice for rickettsial infections and widely used for atypical pneumonia, acne, and Lyme disease.

Rocky Mountain spotted fever

FDA Approved
ChildrenCDC guidance

Evidence Sources

()

Community-acquired pneumonia (atypical)

FDA Approved
AdolescentsIDSA guideline

Evidence Sources

()

Inflammatory acne

FDA Approved
AdolescentsAAD guideline

Secondary Clinical Uses

Lyme disease (neuro or prophylaxis)

Secondary Use
Children and adolescentsIDSA guideline

Off-Label Uses

Note: Off-label uses may be clinically appropriate based on evidence and expert consensus, but are not FDA-approved for these indications. Always consider the evidence base and document clinical reasoning.

Malaria prophylaxis

Off-Label
AdolescentsCDC Yellow Book

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