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Erythromycin (EES) Indications & Clinical Uses

Evidence-based guide for pediatric prescribing

Erythromycin retains key pediatric roles when azithromycin is unavailable or contraindicated.

Primary FDA-Approved Indications

Macrolide with activity against Bordetella pertussis, atypical respiratory pathogens, and Chlamydia species.

Pertussis treatment

FDA Approved
All agesCDC guideline

Evidence Sources

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Neonatal Chlamydia trachomatis conjunctivitis/pneumonia

FDA Approved
NeonatesAAP/CDC guidance

Evidence Sources

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Atypical community-acquired pneumonia

FDA Approved
Children and adolescentsIDSA pediatric CAP guideline

Evidence Sources

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Secondary Clinical Uses

GAS pharyngitis with severe penicillin allergy

Secondary Use
Children and adolescentsIDSA streptococcal pharyngitis guidance

Evidence Sources

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Off-Label Uses

Note: Off-label uses may be clinically appropriate based on evidence and expert consensus, but are not FDA-approved for these indications. Always consider the evidence base and document clinical reasoning.

Pediatric gastroparesis (motilin agonist therapy)

Off-Label
Children and adolescentsSmall studies/expert opinion

Evidence Sources

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