Pediatric Drug Interactions with Esomeprazole

• Review medications that require acidic pH (e.g., atazanavir, rilpivirine, ketoconazole).
• Monitor drugs metabolized by CYP2C19 such as clopidogrel or diazepam.
• Long-term PPI therapy may reduce vitamin B12 and magnesium levels; monitor when combined with other risk agents.