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Peds Calc

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Fluconazole Indications & Clinical Uses

Evidence-based guide for pediatric prescribing

Fluconazole covers Candida species and some endemic fungi with excellent oral absorption.

Primary FDA-Approved Indications

Guideline use includes mucosal candidiasis, candidemia step-down, and prophylaxis in immunocompromised hosts.

Oropharyngeal candidiasis

FDA Approved
Infants and childrenRandomized trials

Evidence Sources

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Esophageal candidiasis

FDA Approved
ChildrenRandomized trials

Candidemia (step-down therapy)

FDA Approved
ChildrenIDSA guideline

Secondary Clinical Uses

Cryptococcal meningitis consolidation/maintenance

Secondary Use
AdolescentsIDSA guideline

Prophylaxis in immunocompromised hosts

Secondary Use
ChildrenClinical trials

Off-Label Uses

Note: Off-label uses may be clinically appropriate based on evidence and expert consensus, but are not FDA-approved for these indications. Always consider the evidence base and document clinical reasoning.

Resistant tinea infections

Off-Label
ChildrenClinical studies

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