Understanding when griseofulvin should not be used and what precautions to take ensures safe and effective treatment of your child's fungal infection. This medication has specific contraindications and important drug interactions that require careful consideration.
Griseofulvin is contraindicated in patients with porphyria and hepatocellular failure. It has significant drug interactions, particularly with warfarin and oral contraceptives, and can cause photosensitivity. The medication requires hepatic metabolism and can rarely cause serious adverse effects including hepatotoxicity and severe skin reactions.
Can cause severe abdominal pain, neurological symptoms, and potentially life-threatening attacks
Risk of drug accumulation and hepatotoxicity
Previous reactions predict future severe responses
Can cause fetal abnormalities, particularly skeletal defects
May worsen photosensitivity and systemic symptoms
Risk of severe sunburn and phototoxic reactions
Limited data on dosing and adverse effects
This medication is generally considered safe during pregnancy and breastfeeding when used as directed. However, if you're pregnant or breastfeeding and need to give this medication to your child, it's always a good idea to discuss this with your healthcare provider to ensure it's the best choice for your specific situation.
Specific drugs: See description
Effect: Unknown effect
How it happens: Induces hepatic enzymes, increasing warfarin metabolism
Management: Consult healthcare provider
Specific drugs: See description
Effect: Unknown effect
How it happens: Enzyme induction reduces contraceptive efficacy
Management: Consult healthcare provider
Specific drugs: See description
Effect: Unknown effect
How it happens: Barbiturates induce griseofulvin metabolism
Management: Consult healthcare provider
Specific drugs: See description
Effect: Unknown effect
How it happens: Disulfiram-like reaction
Management: Consult healthcare provider
Specific drugs: See description
Effect: Unknown effect
How it happens: May reduce cyclosporine levels
Management: Consult healthcare provider
No information available
No information available
No information available
Griseofulvin's contraindication in porphyria is absolute - can trigger life-threatening acute attacks
The warfarin interaction is clinically significant - INR can drop by 50% requiring dose adjustment
Photosensitivity persists for several weeks after discontinuation due to drug deposition in skin
Adolescent females need explicit contraception counseling - document the discussion for liability