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Peds Calc

Safety Information

Ibuprofen Contraindications & InteractionsWhen Not to Use & Important Drug Interactions

Careful screening prevents most serious adverse events with ibuprofen in pediatrics. Review allergies, bleeding risk, kidney status, and co‑medications before use.

Clinical Utility: 8/10
2 Clinical Sources
Back to Ibuprofen Overview

Absolute contraindications: NSAID hypersensitivity and active GI bleeding. Relative contraindications: age <6 months, dehydration/renal impairment, prior peptic ulcer/GI bleed, anticoagulants/antiplatelets/SSRIs/steroids, severe hepatic impairment, uncontrolled hypertension/CV disease, and asthma with NSAID sensitivity.

Contraindications

Absolute Contraindications (Never Use)

NSAID hypersensitivity or aspirin‑exacerbated respiratory disease

Prior bronchospasm, angioedema, or urticaria with NSAIDs indicates risk of severe reactions

Why: COX‑1 inhibition can trigger bronchospasm in susceptible patients

Alternative Options:
Acetaminophen:Different mechanism; no COX‑1 inhibition

Active gastrointestinal bleeding

Any melena, hematemesis, or acute GI hemorrhage

Why: COX‑1/platelet effects and gastric mucosal injury may worsen bleeding

Alternative Options:
Acetaminophen:No platelet effect; less GI irritation

Relative Contraindications (Use With Caution)

Infants under 6 months (unless directed)

Use only with explicit clinician direction

Dehydration or renal impairment

Vomiting/poor intake or pre‑existing renal disease

History of peptic ulcer or GI bleed

Higher risk of recurrence

Pregnancy & Lactation

Avoid in late pregnancy (third trimester). Discuss use during pregnancy or breastfeeding with a clinician.

Clinical References

Ibuprofen – Drug Information•MedlinePlus (2024)expert consensusPediatric data
Ibuprofen for children•NHS (2024)guidelinePediatric data