Understanding how ibuprofen works helps guide safe, effective use in children.
Ibuprofen is a nonselective cyclooxygenase (COX-1 and COX-2) inhibitor that reduces prostaglandin synthesis. Lower prostaglandins decrease inflammation, peripheral pain sensitization, and the hypothalamic set‑point for fever. In pediatrics, these effects translate into improved comfort and reduced temperature when used at appropriate intervals.
Ibuprofen turns down your child’s body signals that cause fever and pain, helping them feel more comfortable while they heal.
Think of it like this: Like turning down the volume on the body’s ‘ouch’ and ‘fever’ dials so kids can rest and recover.
Food can reduce stomach upset because ibuprofen can irritate the stomach lining.
Usually 6–8 hours per dose.
enzyme - reversible_inhibition
Gastric protection and platelet function — inhibition contributes to GI and bleeding risks
enzyme - reversible_inhibition
Inflammation and pain signaling — inhibition yields analgesic/antipyretic effects
Nonselective COX inhibition lowers prostaglandin synthesis, decreasing pain and fever
Bioavailability
High
Time to Peak
1–2 h
Food Effect
Route
Oral
Hepatic oxidation and glucuronidation
Pediatric: Near adult pathways by school age
Half-life
~2 hours
Primary Route
Renal (metabolites)
Dosing Implication
q6–8h dosing typical
Variable gastric emptying may slightly delay onset
Developing hepatic pathways
Higher total body water
Avoid routine use <6 months unless directed
Near adult kinetics
Mature hepatic clearance
Adult‑like
Standard weight‑based dosing applies
Hydration status influences renal safety — hold during dehydration