Clinical pearls to optimize ibuprofen safety and efficacy in children.
Hold ibuprofen during vomiting or poor intake to reduce AKI risk; resume once hydrated
Avoid using multiple NSAIDs; duplicate therapy increases toxicity without added benefit
Give with food or milk to reduce dyspepsia; monitor high‑risk patients for GI bleeding signs
Avoid routine alternating of ibuprofen and acetaminophen due to dosing confusion risk
Alternating antipyretics was commonly recommended
Use a single agent consistently unless clinician advises otherwise
Impact: Fewer dosing errors and better adherence