Ibuprofen is generally safe in pediatrics when dosed by weight. The most common issues are gastrointestinal upset and, less commonly, gastrointestinal bleeding or kidney effects—particularly with dehydration or interacting medicines. Using the lowest effective dose, maintaining hydration, and avoiding duplicate NSAIDs help reduce risk.
nausea, abdominal pain; improves if taken with food or milk
risk rises with prior ulcer, anticoagulants, steroids, or SSRIs
dehydration or combination with ACE inhibitors/ARBs/diuretics increases risk
rash, hives, wheeze in aspirin/NSAID-sensitive patients
avoid in infants <6 months unless specifically directed by a clinician
Key pediatric concerns include GI upset, bleeding risk with certain co-medications, and renal perfusion effects when dehydrated. Simple counseling and vigilance for red flags keep use safe.
2 documented effects
Give with food or milk; avoid duplicate NSAIDs
Report persistent vomiting, severe pain, or black/tarry stools
Avoid if history of GI bleed; use with caution and counsel on warning signs
Black stools, hematemesis, dizziness/pallor warrant urgent care
1 documented effect
Hold during poor intake/vomiting; ensure hydration; avoid triple therapy with ACEi/ARB + diuretic
Decreased urine output or unusual fatigue warrants medical review
1 documented effect
Avoid if history of NSAID-induced bronchospasm/angioedema; educate caregivers
Wheeze, facial swelling, hives—stop and seek care
Dehydration/poor oral intake
History of ulcer/GI bleeding
Concomitant anticoagulants/antiplatelets/SSRIs/steroids
Infants < 6 months (use only if directed)
Information coming soon
Information coming soon
Information coming soon
Information coming soon
Clinical assessment framework
Parent and clinician concerns about Ibuprofen