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Peds Calc

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Lansoprazole Indications & Clinical Uses

Evidence-based guide for pediatric prescribing

Lansoprazole provides potent acid suppression for pediatric GERD, healing of erosive esophagitis, and combination therapy for Helicobacter pylori infection.

Primary FDA-Approved Indications

ODT and capsule sprinkle formulations expand use in younger children. Short courses (6–8 weeks) are typically sufficient for erosive disease; prolonged therapy requires periodic reassessment of risks versus benefits.

Symptomatic gastroesophageal reflux disease

FDA Approved
Children and adolescentsGuideline

Use daily dosing for 4–8 weeks alongside lifestyle modifications; taper when symptoms resolve.

Evidence Sources

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Erosive esophagitis associated with GERD

FDA Approved
Children and adolescentsLabel

Treat for up to 8 weeks; consider maintenance at the lowest effective dose for severe disease.

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Secondary Clinical Uses

Helicobacter pylori eradication (triple therapy)

Secondary Use
Children ≥7 years and adolescentsGuideline

Combine lansoprazole with amoxicillin and clarithromycin or metronidazole for 14 days based on susceptibility.

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Off-Label Uses

Note: Off-label uses may be clinically appropriate based on evidence and expert consensus, but are not FDA-approved for these indications. Always consider the evidence base and document clinical reasoning.

Stress ulcer prophylaxis in critically ill children

Off-Label
ICU patients

Consider when risk factors (mechanical ventilation >48 h, coagulopathy) present; discontinue when risk resolves.

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