Practical advice to improve lansoprazole safety and adherence.
Use ODT for children who cannot swallow capsules and sprinkle granules on acidic soft food for others—never crush granules.
Dose 30 minutes before breakfast (and dinner if BID) to ensure proton pumps are active when lansoprazole binds irreversibly.
When giving via enteral tube, flush with water before and after dosing to prevent clogging from granules.
Plan reassessment after 6–8 weeks; step down to the lowest effective dose or discontinue when symptoms are controlled.