Minocycline shares tetracycline class risks (tooth discoloration, bone deposition) but adds unique toxicities such as vestibular dysfunction, autoimmune reactions, and drug-induced lupus. Screen carefully before prescribing long courses.
Absolute contraindications include hypersensitivity to tetracyclines and pregnancy. Use caution in patients with vestibular disorders, autoimmune history, hepatic impairment, and those on interacting drugs.
Avoid in patients with prior anaphylaxis, severe rash, or angioedema to tetracycline-class antibiotics.
Minocycline can trigger lupus-like syndromes and hepatitis; monitor symptoms and labs closely.
Risk of fetal tooth discoloration and inhibited bone growth; avoid unless no safer alternative exists.
Chronic use can cause tooth discoloration and effects on bone growth; reserve for severe infections when benefits outweigh risks.
Minocycline is hepatically metabolized—dose cautiously and monitor liver function.
Baseline dizziness or vertigo may worsen; consider doxycycline instead.