Pediatric Drug Interactions with Minocycline

• Separate dosing from polyvalent cation supplements and antacids to preserve absorption.
• Monitor INR when combined with warfarin—tetracyclines may potentiate anticoagulation.
• Avoid concurrent systemic retinoids (isotretinoin) due to risk of pseudotumor cerebri.
• Use backup contraception if combined with oral contraceptives—clinical impact is debated but breakthrough bleeding can occur.