Nizatidine is a selective histamine H2 receptor antagonist that reduces gastric acid secretion with minimal effects on hepatic cytochrome P450 enzymes.
Nizatidine is a competitive histamine H2 receptor antagonist that selectively blocks histamine-induced activation of adenylate cyclase in gastric parietal cells. By decreasing intracellular cAMP, it lowers basal and nocturnal gastric acid secretion and reduces pepsin output.
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Half-life
Not specified
Primary Route
Not specified