Pediatric Drug Interactions with Omeprazole

• Avoid routine coadministration with clopidogrel—consider switching to pantoprazole or H2 blocker if antiplatelet therapy is essential.
• Monitor INR when starting or stopping omeprazole in patients taking warfarin.
• Assess antiretroviral regimens (atazanavir, rilpivirine) and antifungals (ketoconazole, itraconazole) that require gastric acidity.