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Peds Calc

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Omeprazole Indications & Clinical Uses

Evidence-based guide for pediatric prescribing

Omeprazole reduces gastric acid and is used in children for GERD and erosive esophagitis.

Primary FDA-Approved Indications

Short‑term therapy improves symptoms and healing in erosive esophagitis; once‑daily dosing is standard.

GERD (symptomatic)

FDA Approved
Children and adolescentsLabelFirst-line

Lifestyle measures alongside medication.

Treatment Duration

Standard: 4–8 weeks

Evidence Sources

Omeprazole — DailyMed ()

Erosive esophagitis

FDA Approved
Children and adolescentsLabelFirst-line

Per label; evaluate maintenance need.

Treatment Duration

Standard: Up to 8 weeks

Evidence Sources

Omeprazole — DailyMed ()

Clinical Decision Support

Quick Selection Guide

Symptom Cluster 1

Symptoms:

  • Heartburn
  • Regurgitation
  • Night cough

Likely Diagnosis:

GERD

Action:

Trial omeprazole and lifestyle measures

Parent Communication Guide

When This Medicine Helps

Understanding the Condition

Too much stomach acid can irritate the esophagus.

Why We Choose This Medicine

This medicine lowers acid and allows healing.

What to Expect

Improvement in 1–2 weeks; reassess at 4–8 weeks.

Monitoring Your Child

Signs the Medicine is Working:

  • Look for gradual symptom improvement and a return to normal activity.

When to Contact Your Doctor:

No improvement after: Discuss with your pediatric care team if symptoms persist.

Watch for these warning signs:

  • Notify your clinician if symptoms worsen, new concerning signs appear, or your child has trouble taking the medication.
Last updated: 9/23/2025
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