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Peds Calc

Safety Information

Ondansetron Contraindications & InteractionsWhen Not to Use & Important Drug Interactions

Review heart history, electrolytes, and medication list before ondansetron.

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Absolute: hypersensitivity, concomitant apomorphine. Relative: congenital long QT, electrolyte abnormalities, concurrent QT‑prolonging agents, severe hepatic impairment, risk for serotonin syndrome with serotonergic stacks.

Contraindications

Absolute Contraindications (Never Use)

Hypersensitivity to ondansetron

Hypersensitivity to ondansetron

Concomitant apomorphine

Concomitant apomorphine

Relative Contraindications (Use With Caution)

Congenital long QT or other significant conduction disease

Congenital long QT or other significant conduction disease

Electrolyte disturbances (low K+/Mg2+)

Electrolyte disturbances (low K+/Mg2+)

Concurrent QT‑prolonging drugs (e.g., certain macrolides, fluoroquinolones)

Concurrent QT‑prolonging drugs (e.g., certain macrolides, fluoroquinolones)

Severe hepatic impairment

Severe hepatic impairment

History of serotonin syndrome with serotonergic combinations

History of serotonin syndrome with serotonergic combinations

Clinical References

Ondansetron – NHS•NHS (2024)
Ondansetron – MedlinePlus•MedlinePlus (2024)