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Peds Calc

Scientific Understanding

How Ondansetron WorksMechanism of Action in Children

By blocking 5‑HT3 receptors, the brain’s nausea pathway is dampened.

Back to Ondansetron Overview

Understanding How Ondansetron Helps Your Child

Ondansetron selectively blocks 5‑HT3 (serotonin) receptors on vagal afferents in the gut and in the chemoreceptor trigger zone, reducing the emetic signaling that leads to nausea and vomiting. This receptor antagonism helps children keep down fluids during recovery.

Molecular Targets & Receptors

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Special Considerations for Children

Infants/childrens

Absorption Changes

Liquid and ODT forms support accurate dosing

Metabolism Changes

Distribution Changes

Clinical Implication

Use weight‑based dosing and screening for cardiac risk

Scientific References

Ondansetron – MedlinePlusMedlinePlus (2024)