Understanding when Pepcid should not be used is straightforward because this medication has very few contraindications. The main concern is allergic reactions to famotidine, which are extremely rare, and dose adjustments for kidney disease.
Pepcid contraindications are minimal, limited to true hypersensitivity reactions and considerations for severe renal impairment. Its lack of significant drug interactions and excellent safety profile make it suitable for most children, including those on multiple medications.
Any history of hypersensitivity reactions to famotidine or other H2 receptor antagonists
Although rare in children, suppressing acid can mask symptoms of underlying serious gastrointestinal disease. Famotidine should not be used as a substitute for thorough evaluation in children with persistent or worsening GI symptoms, unexplained weight loss, or anemia, which could suggest a more serious condition.
Famotidine use in neonates (especially preterm) should be guided by specialists due to altered drug metabolism and increased risk of side effects such as necrotizing enterocolitis. Empiric use in this age group should be avoided without a clear indication and neonatal dosing expertise.
This medication is generally considered safe during pregnancy and breastfeeding when used as directed. However, if you're pregnant or breastfeeding and need to give this medication to your child, it's always a good idea to discuss this with your healthcare provider to ensure it's the best choice for your specific situation.
Specific drugs: See description
Effect: Decreased antifungal effectiveness
How it happens: Reduced gastric acid decreases absorption of these antifungals
Management: Give antifungals 2 hours before famotidine
Specific drugs: See description
Effect: Minimal clinical impact
How it happens: Reduced gastric acid may slightly decrease iron absorption
Management: No specific spacing needed, monitor iron levels if concerned
Specific drugs: See description
Effect: Therapeutic failure of HIV medication
How it happens: Reduced gastric acid significantly decreases atazanavir absorption
Management: Avoid combination or use alternative acid suppression
No information available
No information available
Frequency
Weekly initially, then as needed
Frequency
Ongoing monitoring
Frequency
Regular monitoring based on severity