Famotidine (Pepcid) is generally well tolerated in children. Side effects are typically mild, including headache, dizziness, constipation, and diarrhea. Rarely, allergic reactions or cardiac effects may occur. Below are typical side effects and guidance on monitoring:
Usually mild and transient. Monitoring: report persistent or severe symptoms.
Constipation or diarrhea can occur. Maintain hydration; symptoms often resolve without treatment. Monitoring: seek care if severe or prolonged.
Rash, itching, or swelling are uncommon but warrant immediate medical attention if they occur.
Very rare, typically in renal impairment or with other QT-prolonging drugs. Monitoring: consider ECG in high-risk patients.
Reflux or ulcer pain should improve within a few days. Lack of improvement may require reassessment.
Common side effects of famotidine include headache (4.7%), dizziness (1.3%), constipation (1.2%), and diarrhea (1.7%). Serious events like QT prolongation or allergic reactions are rare.
2 documented effects
Variable
Increase fluids and fiber
Report if severe or persistent
Self-limited
Maintain hydration
Seek care if severe or bloody
3 documented effects
Self-limited
Analgesics as needed
Report persistent headache
Self-limited
Avoid hazardous activities if dizzy
Report persistent dizziness
Until drug cleared
Evaluate renal function; may require dose reduction or discontinuation
Watch for mental status changes
1 documented effect
Until drug clearance
Avoid with other QT-prolonging drugs; monitor ECG in high-risk patients
Baseline and follow-up ECG if risk factors
2 documented effects
Resolves after discontinuation
Topical agents or antihistamines
Discontinue and seek care for severe reactions
Immediate
Emergency treatment (epinephrine)
Seek emergency care if throat swelling or difficulty breathing
1 documented effect
Until drug discontinued
Discontinue drug; supportive care
CBC for unexplained fatigue or bruising
Renal impairment
Concurrent QT-prolonging medications or congenital long QT syndrome
History of H2 blocker hypersensitivity
Long-term high-dose therapy (risk of B12 deficiency)
Take with or without food; adjust dose for kidney function; avoid combining with other acid reducers unless directed; monitor electrolytes in renal impairment.
📞 Call your pediatrician immediately if you notice any of these symptoms:
Hives or swelling of the face or throat
Difficulty breathing or swallowing
Severe dizziness or confusion
Chest palpitations or fainting
Unusual bruising or bleeding
| Effect | Pepcid | Ranitidine |
|---|---|---|
| Potency (H2 blockade) | ≈9× stronger | Baseline |
Reduced antiviral levels due to increased gastric pH
Reduced absorption due to increased gastric pH
Potential increased toxicity; monitor for QT prolongation
For babies taking Pepcid, watch for signs of side effects. This medication is generally well-tolerated in infants when used as directed.
If your toddler is taking Pepcid, they might feel different. This is usually temporary and normal.
Pepcid might cause some side effects in children. Most are mild and go away on their own.
Pepcid can sometimes cause side effects. It's important to take it exactly as prescribed and report any concerns.
A: Pepcid is generally safe when used as prescribed. Most children tolerate it well with minimal side effects.
When to validate: Call if you notice any concerning symptoms or if side effects worsen or persist.
A: Monitor for any changes in behavior, appetite, or energy levels. Most side effects are mild and temporary.
When to validate: Contact us if symptoms are severe or interfere with daily activities.
Clinical assessment framework for Pepcid adverse effects using standardized severity grading.
Parent and clinician concerns about Pepcid