Pediatric Drug Interactions with Prednisolone

• CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce prednisolone levels
• CYP3A4 inhibitors (e.g., azole antifungals, macrolides): may increase steroid exposure
• NSAIDs: additive GI irritation—use with food and counsel
• Live vaccines: avoid during high‑dose/prolonged systemic steroids