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Peds Calc

Scientific Understanding

How Prednisolone WorksMechanism of Action in Children

Gene‑level modulation produces broad anti‑inflammatory effects in the airway.

Quality Score: 8/10
2 Scientific Sources
Back to Prednisolone Overview

Understanding How Prednisolone Helps Your Child

Prednisolone is a glucocorticoid that binds cytosolic glucocorticoid receptors and modulates gene transcription, reducing airway mucosal inflammation, edema, and mucus production while decreasing inflammatory mediator release.

Molecular Targets & Receptors

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Special Considerations for Children

Infants/young childrens

Absorption Changes

Liquid formulations preferred for dose accuracy

Metabolism Changes

Distribution Changes

Clinical Implication

Use oral suspension for precise mg/kg dosing

School‑ages

Absorption Changes

Metabolism Changes

Near adult hepatic handling

Distribution Changes

Clinical Implication

Standard weight‑based dosing applies

Key Clinical Insights

Morning dosing aligns with diurnal cortisol rhythm and reduces insomnia

Evidence: expert_consensusSource:

Short courses minimize HPA axis suppression risk

Evidence: guidelineSource:

Scientific References