Clinical pearls to optimize prednisolone safety and adherence during short pediatric bursts.
Give once‑daily courses in the morning to minimize sleep disturbance and restlessness.
Administer with food or milk to limit stomach upset.
Typical 3–5 day courses do not require tapering unless otherwise directed.
Cap daily dose around 60 mg/day for outpatient pediatric bursts.
Prepare families for transient hyperglycemia; follow sick‑day guidance.
Prefer once‑daily prednisolone bursts when feasible to improve adherence
Twice‑daily dosing commonly used by habit
Once‑daily dosing where tolerated
Impact: Better adherence and fewer missed doses