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Peds Calc

Pediatric Reference

Prednisolone Side EffectsComprehensive Pediatric Safety Guide

Short courses of prednisolone are generally well tolerated in children. Common effects include stomach upset, mood changes, and sleep disturbance. Serious effects are rare with brief bursts but require counseling and monitoring in at‑risk patients.

4 Categories
4 Clinical Sources
Evidence-Based
Back to Prednisolone Overview

Essential Information

1

Gastrointestinal

nausea, stomach upset—give with food

2

Mood/behavior

irritability, restlessness, or euphoria

3

Sleep

difficulty falling asleep, especially with evening doses

4

Metabolic

transient hyperglycemia in at‑risk children

5

Infection

immunomodulation may mask infection symptoms

Clinical Overview

Key pediatric concerns include GI upset, short‑term mood/sleep effects, and transient hyperglycemia in at‑risk children. Dose in the morning with food and keep courses short to minimize risk.

Side Effect Categories

4 Systems

Gastrointestinal

1 documented effect

Total Sources: 1

Dyspepsia, Nausea

Incidence: Common
Onset:
Mild
1 sources
Duration

Management

Give with food or milk; consider morning dosing

Monitoring Guidelines

Persistent vomiting or severe pain warrants evaluation

1 clinical sources• PubMed • Clinical Guidelines • FDA

Neuropsychiatric

1 documented effect

Total Sources: 1

Irritability, Mood Changes, Restlessness

Incidence: Common
Onset:
Usually mild and reversible
1 sources
Duration

Management

Prefer morning dosing; reassure caregivers about short duration

Monitoring Guidelines

Severe agitation, confusion, or persistent symptoms—seek medical review

1 clinical sources• PubMed • Clinical Guidelines • FDA

Endocrine/Metabolic

1 documented effect

Total Sources: 1

Hyperglycemia (transient)

Incidence: Uncommon
Onset:
More relevant in diabetes
1 sources
Duration

Management

Counsel families of children with diabetes; monitor glucose per plan

Monitoring Guidelines

1 clinical sources• PubMed • Clinical Guidelines • FDA

Infection Risk

1 documented effect

Total Sources: 1

Immunomodulation and Masking of Infection

Incidence: Dose- and duration-related
Onset:
Potentially serious
1 sources
Duration

Management

Short bursts generally low risk; evaluate fever persisting or worsening

Monitoring Guidelines

1 clinical sources• PubMed • Clinical Guidelines • FDA

Parent Communication Guide

Age-Appropriate Explanations

Infants (0-12 months)

Information coming soon

Toddlers (1-3 years)

Information coming soon

Children (4-12 years)

Information coming soon

Adolescents (13+ years)

Information coming soon

Common Parent Concerns

Clinical Decision Support

Severity Assessment Framework

Clinical assessment framework

Treatment Decision Guidelines

Immediate Discontinuation

    Consider Alternatives

      Dose Modification

        Frequently Asked Questions

        Parent and clinician concerns about Prednisolone