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Pyrantel Pamoate (base) Indications & Clinical Uses

Evidence-based guide for pediatric prescribing

Pyrantel pamoate is a first-line anthelmintic for luminal nematodes in pediatrics, especially pinworm. Success hinges on repeat dosing and hygiene reinforcement.

Primary FDA-Approved Indications

Use pyrantel for uncomplicated Enterobius infestations and, when other agents are unavailable, for ascariasis or hookworm with clinician monitoring.

Enterobiasis (pinworm)

FDA Approved
≥2 years (clinician-guided if younger)HighFirst-line

Evidence Sources

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Secondary Clinical Uses

Ascariasis

Secondary Use
Children and adolescentsModerate

Evidence Sources

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Off-Label Uses

Note: Off-label uses may be clinically appropriate based on evidence and expert consensus, but are not FDA-approved for these indications. Always consider the evidence base and document clinical reasoning.

Hookworm (Ancylostoma/Necator)

Off-Label
Children ≥2 yearsObservational

Evidence Sources

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•Evidence quality: 85/10
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