Sucralfate is a basic aluminum salt of sucrose octasulfate that acts locally in the GI tract. In acidic environments (pH <4), it polymerizes and cross-links to form a viscous, adherent barrier over injured mucosa.
In an acidic environment (pH <4), sucralfate dissociates into sucrose octasulfate and aluminum hydroxide. The sucrose moiety becomes a viscous, positively charged polymer that binds to exposed proteins in ulcer craters, creating a physical barrier that resists acid, pepsin, and bile salts. It also stimulates endogenous prostaglandin, bicarbonate, and epidermal growth factor production, promoting mucosal blood flow and healing.
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Half-life
Not specified
Primary Route
Not specified