Augmentin Pediatric Dose Calculator

Enter weight, select the prescribed Augmentin strength and regimen, then calculate mg and mL per dose.

Weight (in lbs)

Enter the patient weight in the selected unit.

Weight Unit

Select the unit used for the patient weight.

Medication

Select a medication from your visible list.

Strength

Select the strength of Augmentin

Frequency (2 times per day)

Select how many doses are prescribed per day.

Course: 10 days

Select the prescribed course length in days.

Dosage Amount: 45 mg/kg/day (Standard dose, every 12 h)

Choose the dose written on the prescription. These options are not a recommendation for your child.

Dose is the amoxicillin component. Suspensions are NOT interchangeable: the clavulanate amount differs by product.
90 mg/kg/day must use ES-600 (600 mg/42.9 mg per 5 mL). Using 400/57 or 250/62.5 at this dose doubles to triples the clavulanate and raises diarrhea risk.
200 and 400 mg/5 mL are for every-12-hour dosing; 125 and 250 mg/5 mL are for every-8-hour dosing (label).
Children 40 kg or more: adult dosing; ES-600 has no data above 40 kg (label).
Under 12 weeks: 30 mg/kg/day every 12 hours using 125 mg/5 mL (label).

By using the "Calculate Dose" button on pedscalc.com, you acknowledge and agree that while our calculations aim for accuracy, final prescription responsibility lies solely with you, the healthcare provider. pedscalc.com and its operators are not liable for any errors or omissions, or for the results obtained from the use of this information. Always verify calculations and exercise professional judgment.

amoxicillin-clavulanate mg/kg/day to mL calculator

Augmentin dose calculator: enter weight, choose strength, get mL and mg

Use the Augmentin pediatric dose calculator by entering patient weight, choosing the exact liquid strength, and converting the prescribed amoxicillin-clavulanate mg/kg/day plan into millilitres (mL) and milligrams (mg). The co-amoxiclav pediatric dose calculator uses the same dose per kg math. The amoxicillin component drives the dose target, while 228, 457, and ES-600 formulations change the mL result and clavulanate exposure.

Formula

mL per dose = (child weight in kg x prescribed amoxicillin mg/kg/day / doses per day) / (amoxicillin mg per mL in the selected Augmentin bottle).

Worked example

For a 20 kg child prescribed 45 mg/kg/day divided twice daily, the amoxicillin target is 900 mg/day, or 450 mg per dose. With Augmentin 457, also searched as 400/57 or 400 mg/57 mg per 5 mL, that is 5.6 mL per dose.

Formulation

Strength per 5 mL

Matching search

Calculator setup

Augmentin 228

200 mg amoxicillin + 28.5 mg clavulanate per 5 mL

augmentin 228 dose calculator

Select 200/5 in the calculator, then convert the amoxicillin mg/kg/day target to mL per dose.

Augmentin 457 / 400/57

400 mg amoxicillin + 57 mg clavulanate per 5 mL

augmentin 400/57 5ml dosage calculator

Select 400/5 for 400 mg/57 mg per 5 mL suspension and keep the clavulanate amount visible.

Augmentin ES-600 / 600/42.9

600 mg amoxicillin + 42.9 mg clavulanate per 5 mL

augmentin es-600 dose calculator

Select 600/5 for ES-600 when the prescribed plan calls for the high-dose formulation.

Use case

Dosing focus

Practical check

High-dose otitis media or sinusitis plan

Often uses 80-90 mg/kg/day of the amoxicillin component divided BID, and only with the ES-600 suspension (600 mg/42.9 mg per 5 mL).

Confirm the prescribed formulation and maximum dose before substituting 228, 457, or ES-600.

Standard outpatient bacterial infections

Common plans use 25-45 mg/kg/day of the amoxicillin component, divided by the intended schedule.

Give with food when directed and keep the mL tied to the exact bottle strength.

Clavulanate-sensitive stomach upset

Lower clavulanate exposure may matter when diarrhea or intolerance is a concern, especially when comparing 400/57 with 600/42.9 products.

Do not swap formulations without checking the amoxicillin-to-clavulanate ratio.

Safety checks before using the result

Confirm whether the prescription is written as total amoxicillin mg/kg/day or total mL.
Do not interchange ES-600 with standard Augmentin suspensions by volume.
Use an oral syringe and refrigerate suspension when the label requires it.

Specific dosing support

Common formulation searches for Augmentin

Augmentin 228 Dose CalculatorAugmentin 228 dose calculator support for 200 mg/28.5 mg per 5 mL suspension, with amoxicillin-component mL conversion and clavulanate safety notes.Augmentin 457 Dose CalculatorAugmentin 457 dose calculator support for 400 mg/57 mg per 5 mL suspension, with amoxicillin-component mL conversion and formulation safety checks.Augmentin ES-600 Dose CalculatorAugmentin ES-600 dose calculator support for 600 mg/42.9 mg per 5 mL suspension, with high-dose formulation notes and mL conversion.

Practical dosing guide

Before you measure the dose

Use this page to match the prescribed amoxicillin target to the exact Augmentin bottle strength before you measure the first dose.

Dose based on: Use the amoxicillin component when the prescription is written in mg/kg/day, then convert that target into mL for the exact suspension strength.
Common strengths: Augmentin 228 = 200/28.5 mg per 5 mL, Augmentin 457 or 400/57 = 400 mg/57 mg per 5 mL, and ES-600 = 600 mg/42.9 mg per 5 mL.
Standard vs high dose: Many outpatient plans use 45 mg/kg/day divided twice daily, while high-dose acute otitis media or sinusitis plans may use 90 mg/kg/day divided twice daily with the ES-600 suspension only.

Augmentin 228 dose calculator Augmentin 457 / 400-57 dose calculator Augmentin ES-600 dose calculator Amoxicillin pediatric dose calculator Antibiotic dosing calculators

Augmentin pediatric medication summary

Augmentin (amoxicillin-clavulanate) treats common pediatric bacterial infections such as sinusitis, pneumonia, and otitis media. Use the pediatric dose calculator to convert amoxicillin-based mg/kg/day dosing into mL for common suspension strengths including Augmentin 228, 457, 400/57, and ES-600.

In pediatrics, Augmentin is frequently prescribed for infections such as recurrent or treatment-resistant otitis media, bacterial sinusitis, and pneumonia where beta-lactamase–producing organisms may be present. It is also useful in treating skin and soft tissue infections and some urinary tract infections. The drug is available in various child-friendly formulations, including flavored suspensions, which improve ease of use and adherence for younger patients. Because the clavulanate component can cause gastrointestinal upset, particularly diarrhea, clinicians often select Augmentin formulations with lower clavulanate concentrations (such as the ES-600 version) to reduce this side effect while maintaining efficacy. In summary, Augmentin is a go-to second-line antibiotic in pediatrics when broader bacterial coverage is needed or when first-line therapy is insufficient.

Augmentin indications and common pediatric uses

Augmentin is a trusted antibiotic that helps children fight bacterial infections. Understanding when and how it's used ensures your child receives the right treatment at the right time for their infection.

Recurrent or Treatment-Resistant Otitis Media

Recurrent or Treatment-Resistant Otitis Media: Used as a second-line option in children who have not improved after 48–72 hours of amoxicillin or have received amoxicillin in the past 30 days

Acute Bacterial Sinusitis

Acute Bacterial Sinusitis: Preferred in children with moderate to severe symptoms or suspected beta-lactamase–producing organisms; Augmentin is first-line in guidelines for pediatric bacterial sinusitis

Community-Acquired Pneumonia (Non-Atypical)

Community-Acquired Pneumonia (Non-Atypical): Useful when typical pathogens like *H. influenzae* or beta-lactamase–producing strains are suspected or confirmed, especially in children with recent antibiotic exposure

Skin and Soft Tissue Infections (e.g., Impetigo, Cellulitis)

Skin and Soft Tissue Infections (e.g., Impetigo, Cellulitis): Effective against common skin pathogens including *Staphylococcus aureus* (non-MRSA) and *Streptococcus pyogenes*; often chosen for bite wounds due to polymicrobial coverage

Human or Animal Bite Wounds

Human or Animal Bite Wounds: Recommended for bite-related infections due to its activity against anaerobes and other mixed flora, including *Pasteurella* species

Periorbital (Preseptal) Cellulitis Treated as Outpatient

Periorbital (Preseptal) Cellulitis Treated as Outpatient: Used when MRSA risk is low and imaging/ophthalmology confirm disease is limited to the eyelid. Covers *Streptococcus* and beta-lactamase–producing *H. influenzae* and anaerobes from sinus sources.

How to give Augmentin

This is an administration page where food matters. If you follow the meal timing, storage, and mixing steps closely, you can avoid most of the common side effects and adherence problems families face.
Shake the suspension for at least 15 seconds, then measure the exact prescribed dose with the matching syringe or cup. Give Augmentin at the start of a meal or substantial snack, and ensure any food-mixed dose is fully consumed. Space doses around 12 hours apart, refrigerate after use, and discard the mixed bottle after 10 days.
Put the dose amount in both mL and mg where all caregivers can see it. Pair alarms with breakfast and dinner, keep one backup cooler setup for school days, and use a cold yogurt or drink if taste is difficult. If a child has a history of diarrhea, discuss ES-600 and probiotics with the pediatrician before the course starts.

Augmentin side effects, contraindications, and interactions

Augmentin improves resistant-pathogen coverage but increases gastrointestinal side-effect risk compared with amoxicillin alone. Safe use depends on meal-linked dosing, hydration, clear escalation criteria, and fast reassessment when symptoms worsen.

Common side effects

Gastrointestinal Effects: Diarrhea shows up in 9-19.8% of children; pairing every dose with a meal, keeping fluids up, and adding a probiotic such as Lactobacillus rhamnosus GG or Saccharomyces boulardii (5-40 billion CFU/day) blunts intensity. Call for bloody, persistent (>3 days), or dehydration-driving diarrhea so we can rule out C. difficile or step down therapy.
Hepatotoxicity: Augmentin is the most common antibiotic cause of drug-induced liver injury, but reactions remain rare in kids. High-risk patients (previous liver microinjury, prolonged course) need education on jaundice, dark urine, pale stools, or fatigue and should stop the medicine immediately if those appear; schedule follow-up labs if symptoms or ALT/AST elevations show up.
Drug-Induced Enterocolitis Syndrome (DIES): Severe, repeated vomiting 1-4 hours after a dose without rash or breathing trouble likely represents DIES. Discontinue Augmentin, rehydrate aggressively, and switch to a different antibiotic—do not rechallenge.

Safety checks

Documented immediate hypersensitivity to amoxicillin, clavulanate, or any penicillin-class antibiotic
History of Augmentin-associated cholestatic jaundice or hepatotoxicity
Severe delayed cutaneous reaction to beta-lactams (e.g., Stevens-Johnson syndrome, TEN)
Suspected or confirmed infectious mononucleosis due to predictable widespread rash
Severe renal impairment without dose adjustment
Prior Clostridioides difficile colitis or severe antibiotic-associated diarrhea

Drug interactions

Review the full medication list with a clinician or pharmacist before combining therapies.

Augmentin mechanism and clinical pearls

Augmentin uses two parts that work together. Amoxicillin attacks bacteria by weakening their cell wall, and clavulanate helps prevent bacteria from breaking amoxicillin down before it works.

Give each dose at the start of a full meal whenever possible; this helps clavulanate exposure and reduces gastrointestinal upset.

For children who struggled with side effects on older formulations, ES-600’s lower clavulanate ratio can be a better fit at similar amoxicillin exposure.

A rash during viral illness is often non-allergic, but families need a quick checklist before deciding it is true penicillin allergy.

Starting a probiotic soon after starting treatment is often useful for GI comfort; dose it a few hours apart from antibiotics to avoid overlap.

Use ES-600 selectively for children with prior GI intolerance to standard clavulanate ratios

Frequently asked questions about Augmentin

Augmentin includes clavulanate, which helps amoxicillin work against bacteria that produce enzymes called beta-lactamases. These enzymes make certain bacteria resistant to amoxicillin alone. So if a child has an infection that’s not improving with amoxicillin or has recently taken antibiotics, Augmentin may be used to provide broader coverage and improve effectiveness.

Children typically begin to improve within 48 to 72 hours after starting Augmentin. Fever, pain, and other symptoms should gradually lessen. If there’s no improvement by day three, or if symptoms worsen, contact your pediatrician. The infection may require a different treatment. Always finish the full course of antibiotics unless advised otherwise by your provider.

Diarrhea is a common side effect of Augmentin, especially in younger children. Make sure your child stays hydrated, and talk to your pediatrician about using probiotics during treatment. If the diarrhea is severe, has blood or mucus, or lasts more than a couple of days, stop the medication and contact the provider – this could indicate a more serious issue like C. difficile infection.

Yes, it is recommended to give Augmentin with food or milk to reduce the risk of stomach upset and diarrhea. This is especially important for young children, who may be more sensitive to the gastrointestinal side effects caused by the clavulanate component. Giving it with a snack or meal can help improve tolerance.

If a dose is missed, give it as soon as possible unless it’s close to the time for the next dose – in that case, skip the missed one and continue on schedule. Do not double up on doses. If the child spits out or vomits the dose within 15 minutes, you may need to repeat it. If you’re unsure, call your pediatrician or pharmacist for advice.

It depends on the type of rash. A flat, non-itchy rash might not indicate a true allergy, especially if it occurred several days into treatment and the child was otherwise well. However, hives (itchy, raised welts) or symptoms like swelling or trouble breathing are signs of a true allergic reaction. Always inform your provider about any past reaction. They will help determine if it’s safe to use Augmentin again or if alternatives are needed.

Augmentin dosing is based on the amoxicillin component in mg/kg/day and is usually divided into two doses. Use your clinician's prescribed mg/kg/day target, enter weight, and the calculator converts that into mL per dose for the chosen suspension strength.

Augmentin 228 is the 200 mg amoxicillin / 28.5 mg clavulanate per 5 mL syrup. The dose is still based on the amoxicillin mg/kg/day target, and the calculator converts that to the correct mL for this strength.

They are different suspension strengths, but the dose is still anchored to the amoxicillin component in mg/kg/day. The calculator helps you match the same prescribed target to 228, 457, or ES-600 without doing the syrup math by hand.

IV dosing is clinician-directed and follows hospital protocols. The calculator is intended for standard pediatric oral dosing targets and suspension strengths. Always follow the IV orders from your care team.

Sources reviewed for Augmentin

FDA Approved Labeling for Augmentin
Source
Pediatric Recurrent or Treatment-Resistant Otitis Media Treatment Guidelines
Source
Pediatric Acute Bacterial Sinusitis Treatment Guidelines
Source
Pediatric Community-Acquired Pneumonia (Non-Atypical) Treatment Guidelines
Source
Pediatric Skin and Soft Tissue Infections (e.g., Impetigo, Cellulitis) Treatment Guidelines
Source
Pediatric Human or Animal Bite Wounds Treatment Guidelines
Source

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