Printable Diphenhydramine Dosing Chart
Back to full chart pageUse your browser print dialog (Cmd/Ctrl + P) to print or save as PDF. Always confirm the exact concentration on the bottle and follow clinician guidance.
Diphenhydramine Dosing Chart by Age
AgeUnder 2 years
Dose
Do not use
Interval: —
Max daily: —
Notes: Label: do not use under 2 years. Contraindicated in newborns.
Age2-5 years
Dose
Only if a doctor directs
Interval: —
Max daily: —
Notes: Label: do not use unless directed by a doctor.
Age6-11 years
Dose
12.5-25 mg (5-10 mL)
Interval: every 4-6 h
Max daily: 6 doses (150 mg) in 24 h
Age12 years and older
Dose
25-50 mg (10-20 mL)
Interval: every 4-6 h
Max daily: 6 doses (300 mg) in 24 h
| Age | Dose | Interval | Max daily | Notes |
|---|---|---|---|---|
| Under 2 years | Do not use | — | — | Label: do not use under 2 years. Contraindicated in newborns. |
| 2-5 years | Only if a doctor directs | — | — | Label: do not use unless directed by a doctor. |
| 6-11 years | 12.5-25 mg (5-10 mL) | every 4-6 h | 6 doses (150 mg) in 24 h | — |
| 12 years and older | 25-50 mg (10-20 mL) | every 4-6 h | 6 doses (300 mg) in 24 h | — |
Children's Benadryl Drug Facts (12.5 mg/5 mL) for under 12; 12 years and older from the OTC monograph (21 CFR 341.72). Some store brands say do not use under 4 or 6 years; follow your package.
Doses follow the product Drug Facts label. Charts do not replace labels or clinician guidance. Always verify product concentration and avoid double-dosing with combination products.